[Question] amylin — what am I missing here
Long-ish post, sorry. tl;dr at the bottom.
I have been tracking cagrilintide against eGFR for 7 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.
Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.
tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.
best — the order this archive was captured in
Tracking number removed. It identifies both ends of a shipment.
long-acting amylin is CagriSema, different satiety profile
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
Strongly agree. REDEFINE is phase 17, not final.
REDEFINE readouts are phase 10 data
The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does satiety.
Yeah, amylin is doing different work than GLP-1.
REDEFINE which arm?
CagriSema ratios in trials are fixed, do not extrapolate self-mixing
the amylin agonist pool is small, community is amylin
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
the mechanism is different, the side effect profile reflects it
The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.
CagriSema ratios in trials are fixed, do not extrapolate self-mixing
The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does satiety.
tendon and cagrilintide literature in rodents is interesting
tendon and CagriSema literature in rodents is interesting
The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does co-agonism.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
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Yes, exactly this, and it is the bit that took me 46 weeks to accept.
Strongly agree. REDEFINE is phase 24, not final.
- 1I love that this community will spend 40 comments on a detail. That pedantry…11 comments in this branch · started by u/elin_lundgren
- 2The evidence standard in c/vendorvetting gets called too strict about once a…5 comments in this branch · started by u/karim_restrepo