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c/cagrilintide·submitted 2 years ago by u/ilias_kaufmann

[Question] amylin — what am I missing here

Questionbranch of 5 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking cagrilintide against eGFR for 7 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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5 comments, started 2 years ago
u/karim_restrepo101 points·2 years ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/ms_fragmenter32 points·2 years ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/ilias_kaufmannOP19 points·2 years ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does satiety.

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u/rafael_krastev25 points·2 years ago

tendon and cagrilintide literature in rodents is interesting

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u/ines_ekstrom48 points·2 years ago

tendon and CagriSema literature in rodents is interesting

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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