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c/cagrilintide·submitted 2 years ago by u/ilias_kaufmann

[Question] amylin — what am I missing here

Questionbranch of 11 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking cagrilintide against eGFR for 7 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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11 comments, started 2 years ago
u/elin_lundgren155 points·2 years ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/ravi_sandvik36 points·2 years ago

Strongly agree. REDEFINE is phase 17, not final.

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u/ice_pack_auditcold chain9 points·2 years ago

REDEFINE readouts are phase 10 data

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u/ilias_kaufmannOP6 points·2 years ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does satiety.

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u/laila_dumitru7 points·2 years ago

Yeah, amylin is doing different work than GLP-1.

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u/andres_dahlberg28 points·2 years ago

REDEFINE which arm?

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u/zeynep_duarte6 points·2 years ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/hugo_pires35 points·2 years ago

Rodent or human data?

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u/rania_salinas66 points·2 years ago·edited

the amylin agonist pool is small, community is amylin

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u/nadia_bakker54 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/sulphur_burps_sue76 points·2 years ago·edited

the mechanism is different, the side effect profile reflects it

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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