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c/bloodwork·posted 29 days ago by u/janek_ferrari

week 26 check-in — 31kg down, muscle cramps manageable, one thing confusing me

Concerning

Something I noticed reading old threads that I have not seen said out loud.

The advice on ApoB in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

123 up / 38 down76% upvoted16 commentsid 16al9h30 Jun 2026

16 comments

16 in this archive, depth 5

best — the order this archive was captured in

u/cormac_erdogan28 points·27 days ago

ALT is where the fatty-liver story shows up first

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u/a1c_arcT2D7 points·27 days ago

Not convinced. The evidence does not support that reading.

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u/mariam_mensa2 points·27 days ago

A1c moves slowly, quarterly is plenty

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u/valeria_karlsen2 points·27 days ago

Not convinced.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/kofi_balogun0 points·27 days ago

nobody here can tell you what a result means for you

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u/liver_enzyme_liz1 point·27 days ago

Yeah, baseline matters more than any later number.

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[removed]1 point·27 days ago

[removed by moderator]

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u/transit_variance1 point·26 days ago

HOMA-IR is crude but free and useful for tracking

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u/janek_ferrariOP1 point·27 days ago

Baseline TSH: 99.3. Week 16: 98.6. Same lab, fasted, same time of day. Trend matters.

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u/noor_cardoso22 points·27 days ago·edited

ALT is where the fatty-liver story shows up first

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/step_therapy_s15 points·28 days ago

eGFR noise during rapid loss is expected

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u/tidy_vialdrawer_watch9 points·28 days ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/nnt_nate6 points·28 days ago

eGFR from 2 to 3 is movement, not noise

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u/ahmed_fonseca4 points·28 days ago

post reference ranges with your numbers, units differ by country and lab

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u/janek_ferrariOP3 points·27 days ago

ALT is where the fatty-liver story shows up first

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u/lina_almeida2 points·27 days ago

ApoB over LDL-C, that is the hierarchy

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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