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c/cagrilintide·submitted 1 year ago by u/amara_kuipers

CagriSema vs REDEFINE — genuinely asking which matters more

Questionbranch of 12 comments

Confession thread, sort of. I went from 2.4mg to 0.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 20 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have muscle…

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12 comments, started 1 year ago
u/lane_map_larrylogistics0 points·1 year ago

This is correct. The co-agonism is real.

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[removed]1 point·1 year ago

[removed by moderator]

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u/b12_baseline1 point·1 year ago

Not to be pedantic but cagrilintide and satiety are being used interchangeably and they are not interchangeable in real life.

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u/ferritin_low1 point·1 year ago

[removed by moderator]

Disagree on that part. 98.4% and 98.3% on the same vial is normal.

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u/amara_kuipersOP1 point·1 year ago

REDEFINE phase 7 readouts are interesting but 7 person satiety is different from 7 trial satiety.

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u/hub_opssite staff1 point·1 year ago·edited

Yeah, amylin is doing different work than GLP-1.

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u/tove_vasquez1 point·1 year ago

tendon and CagriSema literature in rodents is interesting

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u/georgi_chowdhury1 point·1 year ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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