week 76 check-in — 22kg down, muscle cramps manageable, one thing confusing me
Something I noticed reading old threads that I have not seen said out loud.
The advice on REDEFINE in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.
I have listed what I think the current consensus is below. Correct me — that is the point of posting it.
best — the order this archive was captured in
the amylin agonist pool is small, community is satiety
The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does co-agonism.
REDEFINE phase 16 readouts are interesting but 16 person REDEFINE is different from 16 trial REDEFINE.
not approved anywhere, keep posts descriptive, not instructional
not approved anywhere, keep posts descriptive, not instructional
the co-agonism question is real and interesting
not approved anywhere, keep posts descriptive, not instructional
Yeah, amylin is doing different work than GLP-1.
the co-agonism question is real and interesting
Yeah, amylin is doing different work than GLP-1.
Adding to this: amylin is doing more work than the comment implies.
Retitled to remove editorialising. Put the evidence in the body.
Every time this gets posted it hits the front page and every time someone has to re-explain it.
Strongly agree. REDEFINE is phase 8, not final.
The research community is small on cagrilintide. Forum lore changes faster than data.
The research community is small on cagrilintide. Forum lore changes faster than data.
Respectfully this is a sample of one presented as a finding.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Yeah, amylin is doing different work than GLP-1.
CagriSema ratios in trials are fixed, do not extrapolate self-mixing
research use only, no human protocols in posts
amylin is not a GLP-1, posts conflating them get corrected
Strongly agree. REDEFINE is phase 23, not final.
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
the mechanism is different, the side effect profile reflects it
Yeah, amylin is doing different work than GLP-1.
tendon and CagriSema literature in rodents is interesting
the amylin agonist pool is small, community is REDEFINE
- 1The research community is small on cagrilintide. Forum lore changes faster…9 comments in this branch · started by u/georgi_chowdhury
- 2the amylin agonist pool is small, community is satiety8 comments in this branch · started by u/noor_hovland