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c/cagrilintide·submitted 14 days ago by u/solene_abubakar

[Discussion] cagri is the most underrated molecule in this space

Discussionbranch of 9 comments

Posting this because I searched for it and got nothing useful. Setup: 0.25mg, week 17, constipation present but not ruining anything. I changed exactly one variable — REDEFINE — and tracked it for 15 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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9 comments, started 13 days ago
u/viktor_nkemelu18 points·13 days ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/solene_abubakarOP8 points·12 days ago

REDEFINE phase 19 readouts are interesting but 19 person amylin is different from 19 trial amylin.

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u/zaid_grimaldi8 points·13 days ago

long-acting amylin is cagrilintide, different satiety profile

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u/ines_ekstrom2 points·12 days ago

amylin receptor distribution is different from GLP-1

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u/andres_dahlberg1 point·12 days ago

amylin receptor distribution is different from GLP-1

Adding to this: REDEFINE is doing more work than the comment implies.

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u/solene_abubakarOP-1 point·12 days ago

The research community is small on cagrilintide. Forum lore changes faster than data.

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u/egfr_watcher1 point·12 days ago

REDEFINE readouts are phase 18 data

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u/hydration_hank1 point·12 days ago

amylin receptor distribution is different from GLP-1

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u/amylin_amyamylin1 point·12 days ago

Yeah, amylin is doing different work than GLP-1.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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