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c/coa·posted 2 years ago by u/dead_space_doug

[Meta] the batch rule is doing its job and people should stop complaining

COA Receipts ×2 Well Actually ×3 Clean Column ×3

Something I noticed reading old threads that I have not seen said out loud.

The advice on certificate of analysis in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

5,000 up / 1,120 down82% upvoted38 commentsid 4u9wrx1 Jan 2024

38 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/andres_restrepo678 points·2 years ago

Crossposting this to c/tirzepatide because the people who need it are not reading this community.

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u/emeka_chowdhury217 points·2 years ago

Sent one vial to VendorInvestigate and Janoshik. 97.2% and 97.4%. Cost me more than the vial did and I would do it again.

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u/cesar_ivaturi449 points·2 years ago

PDF metadata is checkable in fifteen seconds

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u/spreadsheet_gremlindata-24 points·2 years ago

redact your own name, not the vendor's batch details

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u/zaid_balogun1 point·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/teodor_jansen1 point·2 years ago

chromatogram or it did not happen

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u/halima_boateng1 point·2 years ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/foam_head_fred1 point·2 years ago

area% is not mass%, and here is exactly why it matters

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u/sofia_danquah308 points·2 years ago

redact your own name, not the vendor's batch details

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u/tomas_lehtinen239 points·2 years ago

redact your own name, not the vendor's batch details

Adding to this: water content is doing more work than the comment implies.

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u/amara_halonen160 points·2 years ago

the batch number or it did not happen

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u/step_therapy_s120 points·2 years ago

redact your own name, not the vendor's batch details

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[removed]226 points·2 years ago

[removed by moderator]

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u/karma_irrelevant164 points·2 years ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/bastian_moreau120 points·2 years ago

the batch number or it did not happen

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u/dario_vermeulen70 points·2 years ago

Titration speed is a side-effect dial far more than an efficacy dial.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/india_generic_g42 points·2 years ago

axis labels included, always

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u/wrong_network_w111 points·2 years ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/laila_yilmaz91 points·2 years ago

Are you looking at area% or net peptide content? Different numbers.

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u/tomas_lehtinen32 points·2 years ago

This is the correct framing. The COA structure matters as much as the number.

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u/cormac_pereira54 points·2 years ago

the method line is doing real work, not just window dressing

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u/nadia_kjaer13 points·2 years ago

axis labels included, always

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u/bastian_moreau0 points·2 years ago

redact your own name, not the vendor's batch details

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u/dario_boateng72 points·2 years ago

Crossposting this to c/progresspics because the people who need it are not reading this community.

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u/dead_space_dougOP43 points·2 years ago

purity and net content are two different numbers, same vial

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u/nadia_kjaer0 points·2 years ago

the related substances line is where the story is

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u/anecdata_annie1 point·2 years ago

purity and net content are two different numbers, same vial

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u/dead_space_dougOP1 point·2 years ago·edited

Water content was 3.8%, acetate was 6.2%, purity was 99%, but net peptide was only 90% of the label weight. Perfectly honest, just chemistry.

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u/tuva_aalto1 point·2 years ago

the related substances line is where the story is

Disagree on that part. 97.4% and 97.6% on the same vial is normal.

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u/dead_space_dougOP1 point·2 years ago

Asked KP for the batch-specific COA and they sent it within six hours, full document, batch number, date, everything. That is the baseline.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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c/coa rules
  1. Post the full document. Cropped COAs that hide the batch number or date get removed.
  2. Redact your own name and order id, not the vendor's batch details.
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