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c/coa·posted 1 year ago by u/chidi_demir

[Discussion] we are measuring area percent at the wrong time and calling it noise

Discussion Slow Clap ×6 Receipts ×2 Clean Column ×1

area percent. That is the whole post, but I will justify it.

Everything else people worry about in c/sideeffects is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort area percent out first, and almost nobody does.

I say this having got it wrong for 24 months. My triglycerides was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

3,928 up / 399 down91% upvoted57 commentsid zyw36s19 May 2025

57 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/laila_wojcik-32 points·1 year ago

the batch number or it did not happen

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u/camila_lindqvist1 point·1 year ago

Are you looking at area% or net peptide content? Different numbers.

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u/first_hundredMOD1 point·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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[removed]1 point·1 year ago

[removed by moderator]

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u/chidi_demirOP1 point·1 year ago

Asked TFC for the batch-specific COA and they sent it within six hours, full document, batch number, date, everything. That is the baseline.

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u/soren_zamora1 point·1 year ago

Cosigning. The batch number is load-bearing information.

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u/aurel_boateng1 point·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/priya_palacios1 point·1 year ago

Sceptical.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/laila_yilmaz1 point·1 year ago

post the whole document, not the headline number

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u/nikhil_lindqvist368 points·1 year ago

redact your own name, not the vendor's batch details

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u/freya_baptista276 points·1 year ago

the batch number or it did not happen

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u/amylin_amyamylin134 points·1 year ago

Are you looking at area% or net peptide content? Different numbers.

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u/dario_boateng306 points·1 year ago

the related substances line is where the story is

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u/chidi_demir99 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/cormac_pereira142 points·1 year ago

the batch number or it did not happen

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u/nabila_espinoza185 points·1 year ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/yusuf_nakamura148 points·1 year ago

Titration speed is a side-effect dial far more than an efficacy dial.

Disagree on that part. 98.7% and 98.9% on the same vial is normal.

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u/janek_ferrari173 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/tomas_lehtinen122 points·1 year ago

Cosigning. The batch number is load-bearing information.

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u/camila_lindqvist37 points·1 year ago

the batch number or it did not happen

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u/karma_irrelevant147 points·1 year ago

the method line is doing real work, not just window dressing

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u/step_therapy_s46 points·1 year ago

the method line is doing real work, not just window dressing

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/sofia_danquah95 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/amylin_amyamylin68 points·1 year ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/cormac_pereira35 points·1 year ago·edited

purity and net content are two different numbers, same vial

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u/clara_restrepo41 points·1 year ago

purity and net content are two different numbers, same vial

Disagree on that part. 98.7% and 98.3% on the same vial is normal.

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u/chidi_demirOP16 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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u/anecdata_annie9 points·1 year ago

Water content on the document? That affects your concentration math.

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u/zaid_balogun0 points·1 year ago

the batch number or it did not happen

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u/tidy_vialdrawer_watch2814 points·1 year ago

purity and net content are two different numbers, same vial Disagree on that part.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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