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c/compounding·posted 7 months ago by u/quiet_moderator

[Question] 503B — what am I missing here

Question Cold Box ×1

Confession thread, sort of.

I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 23 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have sulphur burps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 83 reads it before doing the same thing.

619 up / 214 down74% upvoted31 commentsid 1pn12q27 Dec 2025

31 comments

22 in this archive, depth 6

best — the order this archive was captured in

u/santiago_rasmussen51 points·7 months ago

Are we talking 503A or 503B?

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u/formulary_fighterappeals35 points·7 months ago

Asked 14 compounders about API source. One told me, one dodged, one said they cannot say. The answer is the signal.

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u/sofia_danquah24 points·7 months ago

shortage list status is 503A, check the actual list

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u/formulary_fighterappeals6 points·7 months ago

Are we talking 503A or 503B?

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u/pavel_kravchenko8 points·7 months ago·edited

This is correct. The shortage list does expire and the rules change.

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u/lipid_panel_larrybloodwork-7 points·7 months ago

503B compounding is different from 503A, different rules, different legality

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u/camila_mensa27 points·7 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/kian_ferreira14 points·7 months ago

telehealth costs 503A plus compounding markup, total varies

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u/quiet_moderatorOPmod8 points·7 months ago

Slight fix: the number was 97.9, not 97.6. Decimal point, but a fairly consequential one.

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u/rohan_steiner4 points·7 months ago

the shortage list is temporary, it ends and compounding becomes illegal again

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u/camila_sandvik1 point·7 months ago·edited

503B compounding is different from 503A, different rules, different legality

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u/usp_appendixcompendial5 points·7 months ago

telehealth prescriber models exist, pricing differs by state

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u/draw_up_dizzy4 points·7 months ago·edited

This is correct. The shortage list does expire and the rules change.

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u/maren_sorensen0 points·7 months ago

Slight fix: the number was 98.7, not 98.6. Decimal point, but a fairly consequential one.

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u/honest_syringe_202513 points·7 months ago

regulatory claims need a citation to the actual rule, not interpretation

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u/formulary_fighterappeals21 points·7 months ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/honest_syringe_202519 points·7 months ago

telehealth prescriber models exist, pricing differs by state

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u/naomi_erdogan5 points·7 months ago

Strongly agree. API source transparency matters.

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u/marit_laurent4 points·7 months ago

telehealth costs shortage list plus compounding markup, total varies

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u/quiet_moderatorMOD18 points·7 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/helga_vermeulen15 points·7 months ago

Strongly agree. API source transparency matters.

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u/quiet_moderatorOPmod10 points·7 months ago

The 503A pharmacy I used lost their shortage list eligibility. Same day, compounding became illegal. Rules are real.

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About c/compounding

Compounded GLP-1s as a supply route: the 503A/503B distinction, the shortage-list mechanics that made compounding legal and then didn't, state board rules, telehealth prescriber models, and what a compounding pharmacy will and will not tell you about its API source.

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