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c/glp1women·posted 1 months ago by u/mateusz_mensah

perimenopause — 8 things I got wrong before I got it right

Caution Clean Column ×8

Genuinely asking, not being difficult.

Everyone in c/orforglipron repeats that insulin resistance is important. I believe it, but I have never seen anyone show why, and when I search I get 20 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

1,359 up / 464 down75% upvoted67 commentsid 15ukpf22 Jun 2026

67 comments

28 in this archive, depth 5

best — the order this archive was captured in

u/signe_villalobos108 points·1 months ago
it is in the wiki actually
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u/hair_shed_hannahMOD60 points·1 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/dose_creep_dan15 points·1 months ago

I am going to push back on this slightly.

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u/mateusz_mensahOP58 points·1 months ago

perimenopause and menopause weight physiology

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[removed]28 points·1 months ago

[removed by moderator]

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u/coa_forgery_watch30 points·1 months ago

Yeah, insulin resistance is under-researched.

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u/elodie_yilmaz7 points·1 months ago

Yeah, contraception is under-researched.

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u/niels_roos6 points·1 months ago

Yeah, contraception is under-researched.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/mateusz_mensahOP3 points·1 months ago

Yeah, insulin resistance is under-researched.

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u/ilias_steiner-6 points·1 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/milan_wikstrom1 point·1 months ago

You have restated the marketing copy. What is the actual substance here.

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u/ewan_zielinski0 points·1 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/idris_kimani1 point·1 months ago

This is correct. PCOS is real.

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u/mateusz_mensahOP1 point·1 months ago

the cycle tracking data matters, keep it private

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u/georgi_haddad1 point·1 months ago·edited

fertility signal is there but unclear

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u/greta_nilsen1 point·1 months ago·edited

the cycle tracking data matters, keep it private

Adding to this: fertility is doing more work than the comment implies.

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u/kian_solberg0 points·1 months ago

contraception interaction claims need citation

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u/honest_syringe1 point·1 months ago

PCOS and insulin resistance

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u/forest_plot_fionastats1 point·1 months ago

hair-loss on contraception is real

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u/rui_only_ro1 point·1 months ago

the PCOS question is under-powered in trials

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u/viktor_laurent1 point·1 months ago

This is correct. PCOS is real.

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u/mateusz_achebe37 points·1 months ago
nope. mine was the opposite.
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u/georgi_haddad21 points·1 months ago

Yeah, contraception is under-researched.

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u/vito_beaulieu16 points·1 months ago

I am going to push back on this slightly.

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u/mateusz_mensah11 points·1 months ago

pregnancy and trying-to-conceive get clinician pointer, not community advice

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u/rasmus_petrescu20 points·1 months ago

This is correct. PCOS is real.

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u/sanne_novak9 points·1 months ago

Small correction: the trial was 20 weeks, not 38. Does not change your point but people will quote it.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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