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c/maintenancephase·submitted 4 months ago by u/fatima_asante

switched from 0.5mg to 2.4mg and the constipation got better, not worse

Metabranch of 5 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking maintenance against eGFR for 21 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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5 comments, started 4 months ago
u/kaplan_meier_kim118 points·4 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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[removed]84 points·4 months ago

[removed by moderator]

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u/fatima_asanteOP60 points·4 months ago

The plateau is real and boring. 76 weeks at the same weight, then movement again. Patience was the intervention.

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u/rafael_krastev28 points·4 months ago

Small correction: the trial was 18 weeks, not 31. Does not change your point but people will quote it.

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u/ilias_nakamura39 points·4 months ago

How long at maintenance?

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The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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