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c/orforglipron·posted 2 months ago by u/kavya_radich

[PSA] non-peptide is not what most of this community thinks it is

Question

Confession thread, sort of.

I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 16 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have muscle cramps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 37 reads it before doing the same thing.

48 up / 16 down75% upvoted14 commentsid 11k3s518 May 2026

14 comments

14 in this archive, depth 5

best — the order this archive was captured in

u/bruno_dumitru5 points·2 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/rasmus_petrescu2 points·2 months ago

the small molecule is whether this actually works long-term

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u/dario_boateng0 points·2 months ago

oral non-peptide agonist is small molecule, no food restrictions

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u/lukas_delgado1 point·2 months ago

the supply conversation changes if this approves

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u/piotr_bruun-13 points·2 months ago

Slight fix: the number was 99.1, not 96.8. Decimal point, but a fairly consequential one.

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u/kavya_radichOP1 point·2 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/blank_injection1 point·2 months ago

Which country? Half the answers in this thread only apply in Spain.

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u/erez_yilmaz1 point·2 months ago

the absorption problem is solved by non-peptide structure

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u/trialwatch_theotrial nerd1 point·2 months ago

the small molecule is whether this actually works long-term

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u/batch_number_bertievetting3 points·2 months ago·edited

small molecule, not a peptide, purity discussion is different

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u/kavya_radichOP2 points·2 months ago

New Zealand here. Waited 3 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/meera_sandvik2 points·2 months ago

small molecule purity is different testing than peptides

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u/hedda_ekstrom2 points·2 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/kavya_radichOP1 point·2 months ago

ATTAIN and ACHIEVE are phase 2 trials

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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