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Single comment threadYou are looking at one branch of small molecule vs ATTAIN — genuinely asking which matters more — 23 comments in the full submission. View in context.
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c/orforglipron·submitted 1 months ago by u/chidi_yilmaz

small molecule vs ATTAIN — genuinely asking which matters more

Speculationbranch of 10 comments

I have had 2 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 6 days on nominally the same lane, which matters more in summer than in February. The independent number came back 98.4% against a claimed…

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10 comments, started 1 months ago
u/maren_sorensen57 points·1 months ago

the supply conversation changes if this approves

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u/fabio_lehtinen32 points·1 months ago

the orforglipron is whether this actually works long-term

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u/hana_lehtinen27 points·1 months ago

no cold chain means ATTAIN, if approved

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u/chidi_yilmazOP14 points·1 months ago

Small correction: the trial was 12 weeks, not 34. Does not change your point but people will quote it.

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[deleted]6 points·1 months ago

[deleted]

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u/trialwatch_theoMOD38 points·1 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/chidi_yilmazOP29 points·1 months ago

phase 5 data is interesting, phase 24 will tell the real story

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u/chidi_yilmazOP17 points·1 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/fabio_lehtinen11 points·1 months ago

the absorption problem is solved by non-peptide structure

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u/laila_delgado6 points·1 months ago

Second this question. I have wondered about ACHIEVE for 9 months and never seen a straight answer.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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