GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of what changed for me between week 60 and week 8 — 50 comments in the full submission. View in context.
2.7k
c/orforglipron·submitted 1 year ago by u/flair_enthusiast

what changed for me between week 60 and week 8

Questionbranch of 8 comments

Right, the oral GLP-1 question again, but with numbers this time. I have 14 data points over 4 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

Read the full submission and all 50 comments →

This branch

8 comments, started 1 year ago
u/ravi_sandvik451 points·1 year ago

small molecule, not a peptide, purity discussion is different

replysharereportpermalink
u/flair_enthusiastOP317 points·1 year ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

replysharereportpermalink
u/purity_pedantanalytical78 points·1 year ago

no cold chain means oral GLP-1, if approved

replysharereportpermalink
u/declared_value_dv153 points·1 year ago

Small correction: the trial was 24 weeks, not 40. Does not change your point but people will quote it.

replysharereportpermalink
u/flair_enthusiastOP-8 points·1 year ago

Week 26 for me and the honest summary is: 7kg down, reflux manageable, and I have thought about food maybe four times today.

replysharereportpermalink
u/batch_number_bertievetting222 points·1 year ago

small molecule, not a peptide, purity discussion is different

replysharereportpermalink
u/jonas_cardoso180 points·1 year ago

small molecule, not a peptide, purity discussion is different

Adding to this: ATTAIN is doing more work than the comment implies.

replysharereportpermalink
u/blank_injection41 points·1 year ago

Strongly agree. The supply impact would be huge.

replysharereportpermalink

← back to the whole thread

About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

21kmembers
62submissions
Feb 2024created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
c/orforglipron rules
  1. Small molecule, not a peptide. Purity discussion here is a different problem.
  2. Cite ATTAIN/ACHIEVE arms specifically when quoting numbers.
  3. Availability speculation must be flaired Speculation.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.