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c/orforglipron·submitted 6 months ago by u/lina_novak

the ACHIEVE question that gets asked weekly, answered properly

Discussionbranch of 6 comments

Confession thread, sort of. I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 19 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have early…

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6 comments, started 6 months ago
u/whois_wanda39 points·6 months ago

Genuine question — what concentration were you at?

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u/chidi_yilmaz10 points·6 months ago

the orforglipron is whether this actually works long-term

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u/lina_novakOP4 points·6 months ago

the orforglipron is whether this actually works long-term

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/lina_novakOP22 points·6 months ago

the small molecule is whether this actually works long-term

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u/ahmed_okafor28 points·6 months ago·edited

Strongly agree. The supply impact would be huge.

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u/muscle_cramp_mo11 points·6 months ago

I am going to push back on this slightly.

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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