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c/orforglipron·posted 7 months ago by u/yannick_salinas

Denmark: ACHIEVE, and what it actually costs here

Question Clean Column ×9

Week 78 update. 4kg down from the start, sulphur burps basically gone since about week 29.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with sulphur burps.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

895 up / 111 down89% upvoted56 commentsid zlx3t324 Dec 2025

56 comments

24 in this archive, depth 5

best — the order this archive was captured in

u/marit_sandvik83 points·7 months ago·edited

phase 15 data is interesting, phase 34 will tell the real story

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u/yannick_salinasOP38 points·7 months ago

Strongly agree. The supply impact would be huge.

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[deleted]25 points·7 months ago

[deleted]

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u/canada_coverage9 points·7 months ago

Disagree. What you are describing is consistent with small molecule, not with what you concluded.

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u/cato_batista67 points·7 months ago

oral non-peptide agonist is ACHIEVE, no food restrictions

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u/yannick_salinasOP41 points·7 months ago

Stalled for 24 weeks, changed nothing, and it started moving again on week 9.

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u/ravi_sandvik32 points·7 months ago·edited

the muscle cramps profile is speculative at this stage

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u/bruno_dumitru10 points·7 months ago

Not to be pedantic but small molecule and orforglipron are being used interchangeably and they are not interchangeable in real life.

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u/kenji_laurent12 points·7 months ago

Which country? Half the answers in this thread only apply in France.

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u/phase_two_peteMOD54 points·7 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/farid_kuipers79 points·7 months ago

Disagree. What you are describing is consistent with small molecule, not with what you concluded.

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u/chidi_yilmaz45 points·7 months ago

This is an urgent-care question wearing a forum question's clothes.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/yannick_salinasOP18 points·7 months ago

ATTAIN and ACHIEVE are phase 11 trials

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u/rasmus_petrescu-22 points·7 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/jonas_cardoso23 points·7 months ago

oral non-peptide agonist is ACHIEVE, no food restrictions

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u/flair_enthusiast0 points·7 months ago

cite ATTAIN/ACHIEVE arms specifically

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u/lucia_bruun25 points·7 months ago

Yeah, small molecule changes the whole game.

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u/maren_sorensen11 points·7 months ago

Week 68 for me and the honest summary is: 7kg down, reflux manageable, and I have thought about food maybe four times today.

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u/fabio_lehtinen5 points·7 months ago

the reflux profile is speculative at this stage

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u/flair_enthusiast20 points·7 months ago

Yeah, small molecule changes the whole game.

Disagree on that part. 98.7% and 98.9% on the same vial is normal.

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u/fatima_kowalski26 points·7 months ago

Strongly agree. The supply impact would be huge.

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u/mateusz_mensah18 points·7 months ago

Not to be pedantic but small molecule and oral GLP-1 are being used interchangeably and they are not interchangeable in real life.

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u/fabio_lehtinen16 points·7 months ago

Which country? Half the answers in this thread only apply in France.

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u/piotr_bruun12 points·7 months ago
post the spreadsheet
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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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