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c/orforglipron·submitted 3 months ago by u/honest_syringe_maybe

ATTAIN — 3 things I got wrong before I got it right

Questionbranch of 5 comments

Trying to settle this properly because the thread from last year went in circles. The claim: small molecule matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 3 months without either producing anything. What would actually settle it is 31 people measuring the…

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5 comments, started 3 months ago
u/ines_lindqvist21 points·3 months ago

Half-life is about 168 hours, so steady state lands around week 12–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/kenji_kimani10 points·3 months ago

small molecule, not a peptide, purity discussion is different

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u/yara_boateng8 points·3 months ago

Which country? Half the answers in this thread only apply in Denmark.

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u/bastian_ekstrom11 points·3 months ago

the nausea profile is speculative at this stage

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u/flair_enthusiast6 points·3 months ago

Respectfully this is a sample of one presented as a finding.

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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