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c/orforglipron·submitted 3 months ago by u/marit_sandvik

non-peptide: what the trials say vs what this community says

Discussionbranch of 8 comments

Been lurking in c/hplc for about 3 months and finally have something worth posting. Short version: week 49, 5mg, and oral GLP-1 is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 7 threads, and the answers split roughly down the middle. What I actually want to know is…

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8 comments, started 2 months ago
u/erez_yilmaz24 points·2 months ago

oral non-peptide agonist is ACHIEVE, no food restrictions

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u/salma_almeida18 points·2 months ago

Stalled for 15 weeks, changed nothing, and it started moving again on week 35.

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u/salma_almeida13 points·2 months ago

phase 10 data is interesting, phase 4 will tell the real story

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u/marit_sandvikOP-20 points·2 months ago

The early fullness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/marit_sandvikOP1 point·2 months ago

The early fullness was genuinely awful for three weeks and then simply stopped.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/bruno_dumitru8 points·2 months ago·edited

Yeah, small molecule changes the whole game.

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u/zeynep_ndiaye6 points·2 months ago

Did anything else change in the same window?

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u/hamza_weiss3 points·2 months ago

small molecule purity is different testing than peptides

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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