non-peptide: what the trials say vs what this community says
Been lurking in c/hplc for about 3 months and finally have something worth posting.
Short version: week 49, 5mg, and oral GLP-1 is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 7 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 55.
best — the order this archive was captured in
oral non-peptide agonist is ACHIEVE, no food restrictions
Stalled for 15 weeks, changed nothing, and it started moving again on week 35.
phase 10 data is interesting, phase 4 will tell the real story
The early fullness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.
The early fullness was genuinely awful for three weeks and then simply stopped.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
Yeah, small molecule changes the whole game.
Did anything else change in the same window?
small molecule purity is different testing than peptides
This is the "correlation is mechanism" thing again. You changed three variables at once.
Every time this gets posted it hits the front page and every time someone has to re-explain it.
availability speculation must be flaired Speculation
Slight fix: the number was 97.6, not 98.3. Decimal point, but a fairly consequential one.
The fatigue was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.
cite ATTAIN/ACHIEVE arms specifically
cite ATTAIN/ACHIEVE arms specifically
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
- 1oral non-peptide agonist is ACHIEVE, no food restrictions8 comments in this branch · started by u/erez_yilmaz
- 2Every time this gets posted it hits the front page and every time someone…7 comments in this branch · started by u/trialwatch_theo