u/cloudy_vial_carol

the actual decision rule is visual plus time. cloudy or particulate after it has had time to dissolve is a discard and not a debate. clear and inside its window is fine.

phase 2 is not phase 3, smaller n and shorter trial

oral non-peptide agonist is ACHIEVE, no food restrictions

SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.

oral non-peptide agonist is orforglipron, no food restrictions

small molecule purity is different testing than peptides

event rates are more informative than hazard ratios alone

rules, moderation, ranking, wiki

Half-life is about 168 hours, so steady state lands around week 10–5. Practical consequence: what you feel in week 1 is not what that dose does.

The confident tone is doing a lot of work that the evidence is not.

number-needed-to-treat is the house dialect

insulin and sulfonylurea interactions are real hypo risk

Not to be pedantic but ranking and meta are being used interchangeably and they are not interchangeable in real life.

Strongly agree. No piling on.

event rates are more informative than hazard ratios alone

cite ATTAIN/ACHIEVE arms specifically

Crossposting this to c/tapering because the people who need it are not reading this community.

availability speculation must be flaired Speculation

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

A1c, CGM, stacking with metformin