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619
c/reconstitution·posted 1 year ago by u/rosa_mensah

small win: dead space stopped being a problem at week 95

Explainer Clean Column ×3

Confession thread, sort of.

I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 23 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have early fullness I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 21 reads it before doing the same thing.

919 up / 300 down75% upvoted27 commentsid lf8xpt5 Aug 2024

27 comments

24 in this archive, depth 4

best — the order this archive was captured in

u/ines_lindqvist0 points·1 year ago

20mg vial, 2mL water, concentration is 20/2 — write it on the vial afterwards

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u/vito_beaulieu0 points·1 year ago

swirl, do not shake, or you are courting oxidation

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u/swirl_dont_shakeMOD1 point·1 year ago·edited

Tracking number removed. It identifies both ends of a shipment.

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u/rina_bergstrom1 point·1 year ago

the concentration on the vial in marker is the most important step

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u/sigrid_kaufmann51 points·1 year ago

Crossposting this to c/semaglutide because the people who need it are not reading this community.

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u/emeka_delgado32 points·1 year ago

bacteriostatic and sterile water are not interchangeable, do not use them that way

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u/niels_roos23 points·1 year ago

the concentration on the vial in marker is the most important step

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u/spain_receta22 points·1 year ago

stopper coring on the 5th draw because you keep using the same entry point. rotate.

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u/soren_zamora5 points·1 year ago

stopper coring on the 5th draw because you keep using the same entry point.

Disagree on that part. 98.1% and 98.4% on the same vial is normal.

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u/gradient_goblin1 point·1 year ago

Small correction: the trial was 20 weeks, not 9. Does not change your point but people will quote it.

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[removed]1 point·1 year ago

[removed by moderator]

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u/sleep_apnea_sam19 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 5–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/alcohol_aversion12 points·1 year ago

Respectfully this is a sample of one presented as a finding.

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u/honest_syringe_maybe4 points·1 year ago

bacteriostatic and sterile water are not interchangeable, do not use them that way

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u/ruben_cabrera12 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 5–5.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/escrow_evangelist10 points·1 year ago

show your working or it is unhelpful

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u/sofia_danquah9 points·1 year ago

Dead space ate 2 units on a low-volume draw. Tiny impact at 2.4mg, massive impact at 10mg.

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u/ruben_cabrera6 points·1 year ago·edited

Cosigning. The concentration on the vial in marker is load-bearing.

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u/soren_zamora5 points·1 year ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/reflux_report4 points·1 year ago

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/rosa_mensahOP4 points·1 year ago

stopper coring on the 7th draw because you keep using the same entry point. rotate.

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u/hedda_ekstrom6 points·1 year ago

Did you write the concentration on the vial?

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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