GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of triple agonist: the version I wish someone had shown me in week 1 — 13 comments in the full submission. View in context.
8k
c/retatrutide·submitted 2 years ago by u/iman_castellanos

triple agonist: the version I wish someone had shown me in week 1

Discussionbranch of 8 comments

Confession thread, sort of. I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 15 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have muscle…

Read the full submission and all 13 comments →

This branch

8 comments, started 2 years ago
u/arne_amankwah1.1k points·2 years ago

triple agonism is dose escalation, do not generalise

replysharereportpermalink
u/noor_ivaturi258 points·2 years ago·edited

This is correct. Triple agonism is genuinely different.

replysharereportpermalink
u/nikhil_asante302 points·2 years ago

The glucagon component does different things than dual agonism. The early fullness are not just amplified versions.

replysharereportpermalink
u/nadia_trevino91 points·2 years ago

The glucagon component does different things than dual agonism.

Yes, exactly this, and it is the bit that took me 82 weeks to accept.

replysharereportpermalink
u/mod_cold_roommod · c/coldchain62 points·2 years ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

replysharereportpermalink
u/blunt_coldbox_202480 points·2 years ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

replysharereportpermalink
u/elodie_grimaldi80 points·2 years ago

heart rate and dose escalation need actual measurements, not impressions

replysharereportpermalink
u/viktor_laurent18 points·2 years ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

replysharereportpermalink

← back to the whole thread

About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

65kmembers
130submissions
Sep 2023created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
More in c/retatrutide
c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/reta_and_regretu/trialwatch_theou/incretin_ivyu/ledger_mod
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →