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c/retatrutide·posted 2 years ago by u/zeynep_mbeki

retatrutide — my 13-week log, condensed into one table

Question Well Actually ×3

Been lurking in c/sideeffects for about 12 months and finally have something worth posting.

Short version: week 74, 1.0mg, and triple agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 13 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 80.

669 up / 216 down76% upvoted27 commentsid 1bbsh121 Nov 2023

27 comments

24 in this archive, depth 5

best — the order this archive was captured in

u/injection_site_iris97 points·2 years ago·edited

What was the dosing schedule in that arm?

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u/kofi_balogun61 points·2 years ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/tired_ledger_notes45 points·2 years ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/liver_enzyme_liz15 points·2 years ago

research use only, handling and analysis, not protocols

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u/niels_lindqvist14 points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/farid_molnar48 points·2 years ago·edited

nobody should be giving this to anyone without extensive monitoring

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u/zeynep_mbekiOP28 points·2 years ago

heart rate and dose escalation need actual measurements, not impressions

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u/iman_castellanos33 points·2 years ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/incretin_ivypharmacology0 points·2 years ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/reta_and_regretMOD1 point·2 years ago

Tracking number removed. It identifies both ends of a shipment.

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u/naomi_erdogan1 point·2 years ago

Tracking number removed.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/rekha_vestergaard0 points·2 years ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/kofi_balogun1 point·2 years ago

Inter-lab variance on this kind of assay is routinely 1–2 points.

Yes, exactly this, and it is the bit that took me 13 weeks to accept.

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u/kavya_kravchenko43 points·2 years ago

You have restated the marketing copy. What is the actual substance here.

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u/nadia_trevino17 points·2 years ago

the glucagon component changes the side effect profile, not just the efficacy

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u/blunt_coldbox_2024-28 points·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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u/zeynep_mbekiOP1 point·2 years ago

The glucagon component does different things than dual agonism. The sulphur burps are not just amplified versions.

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u/farid_molnar1 point·2 years ago

That is net peptide content, not purity.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/quiet_moderatormod1 point·2 years ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/burned_once_twice23 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/helga_vermeulen31 points·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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u/viktor_laurent9 points·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/kofi_balogun6 points·2 years ago

research use only, handling and analysis, not protocols

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u/rekha_vestergaard3 points·2 years ago

phase 2 numbers are not maintenance numbers, cite the trial

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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