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c/retatrutide·submitted 4 days ago by u/liver_enzyme_liz

[Lab] two reta batches, two services, 98.4% and 97.9%

Labbranch of 9 comments

Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 3 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…

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9 comments, started 2 days ago
u/bilal_osei55 points·2 days ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/iman_castellanos38 points·2 days ago

This is correct. Triple agonism is genuinely different.

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u/freya_baptista35 points·2 days ago

The glucagon component does different things than dual agonism. The reflux are not just amplified versions.

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u/incretin_ivypharmacology17 points·2 days ago

The glucagon component does different things than dual agonism.

Adding to this: TRIUMPH is doing more work than the comment implies.

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u/noor_ivaturi8 points·2 days ago

nobody should be giving this to anyone without extensive monitoring

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u/arne_amankwah4 points·2 days ago

This is correct. Triple agonism is genuinely different.

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u/emil_agyeman2 points·2 days ago

triple agonism is glucagon, do not generalise

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u/injection_site_iris15 points·2 days ago

The glucagon component does different things than dual agonism.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/burned_once_twice29 points·2 days ago·edited

phase 2 numbers are not maintenance numbers, cite the trial

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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