[Lab] two reta batches, two services, 98.4% and 97.9%
Genuinely asking, not being difficult.
Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 3 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
Titration speed is a side-effect dial far more than an efficacy dial.
retatrutide is not approved anywhere for human use, posts must not read as instructions
heart rate and dose escalation need actual measurements, not impressions
Disagree. What you are describing is consistent with retatrutide, not with what you concluded.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
heart rate and dose escalation need actual measurements, not impressions
That is net peptide content, not purity. Different number, different meaning.
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
nobody should be giving this to anyone without extensive monitoring
the weight curves are unusually steep, which makes predicting individual response harder
The confident tone is doing a lot of work that the evidence is not.
TRIUMPH phase 2 showed 99.2% weight loss but the early fullness profile on the highest arm was rough. Phase 2 != phase 3.
triple agonism is glucagon, do not generalise
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
phase 2 numbers are not maintenance numbers, cite the trial
Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.
This is correct. Triple agonism is genuinely different.
The glucagon component does different things than dual agonism. The reflux are not just amplified versions.
The glucagon component does different things than dual agonism.
Adding to this: TRIUMPH is doing more work than the comment implies.
nobody should be giving this to anyone without extensive monitoring
This is correct. Triple agonism is genuinely different.
triple agonism is glucagon, do not generalise
The glucagon component does different things than dual agonism.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
phase 2 numbers are not maintenance numbers, cite the trial
retatrutide is not approved anywhere for human use, posts must not read as instructions
- 1The heart rate signal in TRIUMPH is real and concerning. Higher doses had…11 comments in this branch · started by u/mateusz_mensah
- 2Dose escalation on retatrutide is steeper and faster than on semaglutide. Do…9 comments in this branch · started by u/bilal_osei