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c/retatrutide·submitted 4 days ago by u/liver_enzyme_liz

[Lab] two reta batches, two services, 98.4% and 97.9%

Labbranch of 11 comments

Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 3 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…

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11 comments, started 3 days ago
u/mateusz_mensah72 points·3 days ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/blunt_coldbox_20240 points·3 days ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/liver_enzyme_lizOP1 point·3 days ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/ewan_marchand1 point·3 days ago

nobody should be giving this to anyone without extensive monitoring

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u/ewan_zielinski1 point·3 days ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/liver_enzyme_lizOP1 point·3 days ago·edited

The confident tone is doing a lot of work that the evidence is not.

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u/nadia_trevino59 points·3 days ago

TRIUMPH phase 2 showed 99.2% weight loss but the early fullness profile on the highest arm was rough. Phase 2 != phase 3.

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[deleted]21 points·3 days ago

[deleted]

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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