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c/retatrutide·posted 11 months ago by u/discount_math_dm

is it normal to get nausea at week 65

Discussion Well Actually ×7 Cold Box ×2 Long Haul ×3

Been lurking in c/sideeffects for about 10 months and finally have something worth posting.

Short version: week 67, 15mg, and triple agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 25 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 73.

8,780 up / 3,100 down74% upvoted40 commentsid 1nzzjb12 Aug 2025

40 comments

6 in this archive, depth 3

best — the order this archive was captured in

u/nordic_pricing361 points·11 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/anya_moreau0 points·11 months ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/quiet_moderatormod1 point·11 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/burned_once_twice116 points·11 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/andres_sorensen-22 points·11 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
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