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c/retatrutide·submitted 1 year ago by u/trialwatch_theo

dose escalation: the version I wish someone had shown me in week 1

Discussionbranch of 6 comments

Confession thread, sort of. I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 10 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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6 comments, started 1 year ago
u/iman_castellanos394 points·1 year ago·edited

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/tired_ledger_notes101 points·1 year ago·edited

This is correct. Triple agonism is genuinely different.

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u/nikhil_asante84 points·1 year ago

Are you quoting phase 2 or is there phase 3 data now?

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u/yannick_barros80 points·1 year ago

triple agonism is phase 2, do not generalise

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u/trialwatch_theoOPtrial nerd60 points·1 year ago

The glucagon component does different things than dual agonism. The injection-site soreness are not just amplified versions.

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u/cold_chromatogram_only37 points·1 year ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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