[Results] 2 weeks, 6kg, and retatrutide was the hard part
phase 2. That is the whole post, but I will justify it. Everything else people worry about in c/glp1canada is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort phase 2 out first, and almost nobody does. I say this having got it wrong for 23 months. My ApoB was the…
triple agonism is phase 2, do not generalise
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
This is correct. Triple agonism is genuinely different.
nobody should be giving this to anyone without extensive monitoring
Not to be pedantic but glucagon and triple agonist are being used interchangeably and they are not interchangeable in real life.
Respectfully this is a sample of one presented as a finding.
triple agonism is dose escalation, do not generalise
This is correct. Triple agonism is genuinely different.
phase 2 numbers are not maintenance numbers, cite the trial
The heart rate signal in TRIUMPH is real and concerning.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
the weight curves are unusually steep, which makes predicting individual response harder