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c/retatrutide·submitted 2 years ago by u/mateusz_mensah

[Discussion] the glucagon advice in here is 17 years out of date

Discussionbranch of 8 comments

Quick one. Canada here. glucagon works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 20 weeks and cost roughly what I expected. The admin was worse than the…

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8 comments, started 2 years ago
u/freya_baptista242 points·2 years ago

Which trial arm and what was the n?

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u/ewan_marchand78 points·2 years ago·edited

Respectfully this is a sample of one presented as a finding.

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u/mateusz_mensahOP0 points·2 years ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/rosa_almeida1 point·2 years ago

the 15mg arm is different from 12.5mg, results do not transfer

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u/quiet_moderatormod120 points·2 years ago

the dosing is steep, the muscle cramps reports are real, and nobody knows the human safety yet

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u/farid_molnar98 points·2 years ago·edited

This is correct. Triple agonism is genuinely different.

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u/yara_lindholm32 points·2 years ago·edited

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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[deleted]12 points·2 years ago

[deleted]

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Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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