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c/retatrutide·submitted 1 year ago by u/incretin_ivy

what would you tell week-1 you about dose escalation

Trial Databranch of 6 comments

phase 2. That is the whole post, but I will justify it. Everything else people worry about in c/glp1women is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort phase 2 out first, and almost nobody does. I say this having got it wrong for 23 months. My hs-CRP…

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6 comments, started 1 year ago
u/nadia_norgaard94 points·1 year ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/cormac_roos-37 points·1 year ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/incretin_ivyOPpharmacology1 point·1 year ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/halima_mbeki79 points·1 year ago

You have restated the marketing copy. What is the actual substance here.

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u/bilal_osei21 points·1 year ago

heart rate and dose escalation need actual measurements, not impressions

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u/andres_restrepo25 points·1 year ago

heart rate and dose escalation need actual measurements, not impressions

Yes, exactly this, and it is the bit that took me 48 weeks to accept.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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