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c/retatrutide·submitted 1 year ago by u/incretin_ivy

what would you tell week-1 you about dose escalation

Trial Databranch of 10 comments

phase 2. That is the whole post, but I will justify it. Everything else people worry about in c/glp1women is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort phase 2 out first, and almost nobody does. I say this having got it wrong for 23 months. My hs-CRP…

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10 comments, started 1 year ago
u/reta_and_regretMOD257 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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[removed]189 points·1 year ago

[removed by moderator]

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u/nausea_notesside effects46 points·1 year ago

the dosing is steep, the the food-noise thing reports are real, and nobody knows the human safety yet

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u/careful_gradient_again11 points·1 year ago

the glucagon component changes the side effect profile, not just the efficacy

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u/incretin_ivyOPpharmacology19 points·1 year ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/renzo_yildiz92 points·1 year ago

[removed by moderator]

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

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u/zeynep_mbeki146 points·1 year ago

This is correct. Triple agonism is genuinely different.

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u/andres_restrepo77 points·1 year ago

heart rate and dose escalation need actual measurements, not impressions

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u/customs_seizure_sid21 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/incretin_ivyOPpharmacology112 points·1 year ago

research use only, handling and analysis, not protocols

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
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