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c/retatrutide·submitted 1 months ago by u/nadia_trevino

what would you tell week-1 you about triple agonist

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Week 12 update. 13kg down from the start, muscle cramps basically gone since about week 52. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps. The part that surprised me is how much of this is admin.…

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6 comments, started 1 months ago
u/renzo_yildiz4 points·1 months ago

Mechanistically the bit that matters is TRIUMPH. It explains most of the early profile and a decent chunk of the outcome.

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[removed]2 points·1 months ago

[removed by moderator]

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u/arne_amankwah6 points·1 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/reta_and_regret4 points·1 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/aa_analysis_andy2 points·1 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/nausea_notesside effects-37 points·1 months ago

the 1.0mg arm is different from 0.5mg, results do not transfer

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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