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c/retatrutide·submitted 3 months ago by u/ledger_mod

help me understand glucagon, I have read the wiki twice

Questionbranch of 8 comments

Been lurking in c/sideeffects for about 5 months and finally have something worth posting. Short version: week 24, 1.7mg, and triple agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 39 threads, and the answers split roughly down the middle. What I actually want to…

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8 comments, started 3 months ago
u/two_mil_or_one495 points·3 months ago

the glucagon component changes the side effect profile, not just the efficacy

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u/ledger_modOPmod · vetting347 points·3 months ago

the glucagon component changes the side effect profile, not just the efficacy

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/placebo_arm_pam167 points·3 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/trialwatch_theotrial nerd125 points·3 months ago

Which trial arm and what was the n?

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u/ledger_modOPmod · vetting74 points·3 months ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/hugo_pires120 points·3 months ago·edited

the glucagon component changes the side effect profile, not just the efficacy Counter-anecdote: opposite result, same dose.

Disagree on that part. 98.7% and 95.1% on the same vial is normal.

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u/marta_vanhecke155 points·3 months ago

Which trial arm and what was the n?

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u/ledger_modOPmod · vetting99 points·3 months ago·edited

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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