why does nobody talk about triple agonist
Quick one. Canada here.
glucagon works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.
Specifics: the route I used took 7 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.
Happy to answer questions from anyone in the same jurisdiction.
best — the order this archive was captured in
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
Titration speed is a side-effect dial far more than an efficacy dial.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
The glucagon component does different things than dual agonism. The early fullness are not just amplified versions.
the weight curves are unusually steep, which makes predicting individual response harder
Strongly agree. Heart rate escalation needs the actual data, not impressions.
Small correction: the trial was 5 weeks, not 11. Does not change your point but people will quote it.
TRIUMPH phase 2 showed 98.7% weight loss but the injection-site soreness profile on the highest arm was rough. Phase 2 != phase 3.
nobody should be giving this to anyone without extensive monitoring
the glucagon component changes the side effect profile, not just the efficacy
phase 2 numbers are not maintenance numbers, cite the trial
TRIUMPH phase 2 showed 98.6% weight loss but the injection-site soreness profile on the highest arm was rough. Phase 2 != phase 3.
phase 2 numbers are not maintenance numbers, cite the trial
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
Flair changed to match the content. Read the sidebar before posting next time and we are square.
Not to be pedantic but dose escalation and retatrutide are being used interchangeably and they are not interchangeable in real life.
the dosing is steep, the early fullness reports are real, and nobody knows the human safety yet
Not to be pedantic but retatrutide and TRIUMPH are being used interchangeably and they are not interchangeable in real life.
Small correction: the trial was 22 weeks, not 15. Does not change your point but people will quote it.
Small correction: the trial was 22 weeks, not 15.
Adding to this: dose escalation is doing more work than the comment implies.
I am going to push back on this slightly.
the 2.5mg arm is different from 1.0mg, results do not transfer
the 12.5mg arm is different from 10mg, results do not transfer
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
the glucagon component changes the side effect profile, not just the efficacy
Strongly agree. Heart rate escalation needs the actual data, not impressions.
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
- 1Water content matters more than people think. If a vial is carrying residual…11 comments in this branch · started by u/trialwatch_theo
- 2phase 2 numbers are not maintenance numbers, cite the trial6 comments in this branch · started by u/incretin_ivy