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c/retatrutide·submitted 5 months ago by u/placebo_arm_pam

why does nobody talk about triple agonist

Resultsbranch of 11 comments

Quick one. Canada here. glucagon works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 7 weeks and cost roughly what I expected. The admin was worse than the…

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11 comments, started 5 months ago
u/trialwatch_theotrial nerd209 points·5 months ago·edited

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/ledger_modmod · vetting174 points·5 months ago·edited

Titration speed is a side-effect dial far more than an efficacy dial.

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u/trialwatch_theotrial nerd52 points·5 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/placebo_arm_pamOP-21 points·5 months ago

The glucagon component does different things than dual agonism. The early fullness are not just amplified versions.

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u/ewan_zielinski-32 points·5 months ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/ewan_marchand1 point·5 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/sena_teixeira1 point·5 months ago

Small correction: the trial was 5 weeks, not 11. Does not change your point but people will quote it.

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u/placebo_arm_pamOP1 point·5 months ago

TRIUMPH phase 2 showed 98.7% weight loss but the injection-site soreness profile on the highest arm was rough. Phase 2 != phase 3.

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u/anya_moreau166 points·5 months ago

nobody should be giving this to anyone without extensive monitoring

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[deleted]77 points·5 months ago

[deleted]

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u/divya_bakken100 points·5 months ago

the glucagon component changes the side effect profile, not just the efficacy

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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