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Single comment threadYou are looking at one branch of [Discussion] can we stop arguing about glucagon until somebody posts a number — 54 comments in the full submission. View in context.
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c/retatrutide·submitted 6 months ago by u/andres_restrepo

[Discussion] can we stop arguing about glucagon until somebody posts a number

Discussionbranch of 8 comments

Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 24 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…

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8 comments, started 6 months ago
u/hassan_nilsen397 points·6 months ago·edited

the dosing is steep, the early fullness reports are real, and nobody knows the human safety yet

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u/solene_ilunga164 points·6 months ago

Small correction: the trial was 7 weeks, not 36. Does not change your point but people will quote it.

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u/careful_gradient3298 points·6 months ago

Did you actually measure heart rate or is that a feeling?

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u/liver_enzyme_liz60 points·6 months ago

the 15mg arm is different from 0.25mg, results do not transfer

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u/titration_marshalmod · c/semaglutide35 points·6 months ago

the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet

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u/baseline_drifteranalytical8 points·6 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/andres_restrepoOP26 points·6 months ago

Respectfully this is a sample of one presented as a finding.

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u/rohan_cardoso139 points·6 months ago·edited

nobody should be giving this to anyone without extensive monitoring

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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