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c/semaglutide·posted 2 years ago by u/ahmed_abubakar

week 36 check-in — 27kg down, sulphur burps manageable, one thing confusing me

Discussion Receipts ×4 Clean Column ×2 Well Actually ×2

Right, the weekly dosing question again, but with numbers this time.

I have 9 data points over 40 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 82, not week 36. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

7,413 up / 832 down90% upvoted49 commentsid 8gcbqt27 May 2024

49 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/two_mil_or_one611 points·2 years ago

Cosigning. The slow route gets the outcome, the fast route gets you the side effects.

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u/greta_lokken335 points·2 years ago

What was the method? "HPLC" is a technique, not a method.

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u/micro_bump_mick0 points·2 years ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/ahmed_abubakarOP1 point·2 years ago

Went up because the scale stalled, not because I needed to. Do not be me. The stall broke on its own at the higher dose.

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u/dose_creep_dan1 point·2 years ago

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

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u/greta_lokken1 point·2 years ago

Cosigning. The slow route gets the outcome, the fast route gets you the side effects.

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u/archived_thread_a1 point·2 years ago

Small correction: the trial was 14 weeks, not 17. Does not change your point but people will quote it.

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u/meta_analysis_mo230 points·2 years ago

Half-life is about 168 hours, so steady state lands around week 22–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/ines_castellanos51 points·2 years ago

Disagree. What you are describing is consistent with Wegovy, not with what you concluded.

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u/sofia_wikstrom123 points·2 years ago
fair enough
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u/ahmed_abubakarOP180 points·2 years ago

week 16 and i am still not at maintenance, do not rush the ladder

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u/oskar_kaufmann77 points·2 years ago

titration speed is weekly dosing plus side effects, period

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u/rafael_ostergaard0 points·2 years ago

nope, 0.25 counts, it is just not the dose most people stay on

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[removed]54 points·2 years ago

[removed by moderator]

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u/hassan_castellanos38 points·2 years ago

[removed by moderator]

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/ahmed_abubakarOP31 points·2 years ago

my eGFR moved before the scale did and i nearly missed it

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