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c/sideeffects·posted 1 months ago by u/hassan_castellanos

am I the only one who found heart rate harder than the injections

Management Cold Box ×7

Confession thread, sort of.

I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 23 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have injection-site soreness I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 32 reads it before doing the same thing.

723 up / 240 down75% upvoted33 commentsid 1ah6oh2 Jun 2026

33 comments

24 in this archive, depth 4

best — the order this archive was captured in

u/graph_it_gary54 points·1 months ago

This is correct. The muscle cramps is horrible for three weeks and then just ends.

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u/elin_lindqvist43 points·1 months ago·edited

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/aleksi_lehtinen34 points·1 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

Adding to this: heart rate is doing more work than the comment implies.

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u/ilias_cabrera41 points·1 months ago

Same experience. Week 55 and it simply stopped. I know that is not useful information but it is what happened.

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u/rekha_mbeki33 points·1 months ago

Same experience. Week 49 and it simply stopped. I know that is not useful information but it is what happened.

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u/elin_lundgren21 points·1 months ago

Same experience. Week 10 and it simply stopped. I know that is not useful information but it is what happened.

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u/ayesha_erdogan26 points·1 months ago

Mechanistically the bit that matters is constipation. It explains most of the early profile and a decent chunk of the outcome.

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u/signe_villalobos17 points·1 months ago

The sulphur burps passes. I kept a log and the timeline was the only useful thing. 16 weeks and it was basically gone.

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u/quiet_moderatormod5 points·1 months ago

Half-life is about 168 hours, so steady state lands around week 18–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/insulin_syringe_ian1 point·1 months ago

early fullness at 2.4mg is different from 2.5mg

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u/mikkel_kimani3 points·1 months ago

hair loss is real and usually reversible when you stabilize

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u/brigade_detector10 points·1 months ago

the reflux passes. i promise. not medical advice.

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u/zeynep_ndiaye12 points·1 months ago

Resting heart rate up 7 bpm from baseline, settled back down once I stopped escalating. Tracked daily so I am confident.

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u/long_post_larry8 points·1 months ago

Crossposting this to c/glp1canada because the people who need it are not reading this community.

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u/emil_barros3 points·1 months ago

Are you on a pen or research vial? The formulation changes the profile.

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u/ayesha_erdogan0 points·1 months ago

the food-noise thing stops around week 64 for most people

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u/hassan_castellanosOP1 point·1 months ago

the food-noise thing stops around week 22 for most people

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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