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c/sideeffects·posted 4 months ago by u/piotr_bruun

heart rate: what the trials say vs what this community says

Management Well Actually ×4

Something I noticed reading old threads that I have not seen said out loud.

The advice on sulphur burps in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

831 up / 294 down74% upvoted32 commentsid 1b1r0g4 Mar 2026

32 comments

23 in this archive, depth 4

best — the order this archive was captured in

u/ayesha_radich125 points·4 months ago

Yeah, the nausea hit on day 9 for me too, not day 1.

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u/sanne_laurent63 points·4 months ago

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

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u/liv_vukovic41 points·4 months ago·edited

week 25 and the early fullness is finally getting better

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u/rohan_steiner88 points·4 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/ferritin_low59 points·4 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points.

Yes, exactly this, and it is the bit that took me 32 weeks to accept.

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[removed]40 points·4 months ago

[removed by moderator]

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u/aleksi_lehtinen68 points·4 months ago

Slight fix: the number was 99.1, not 99.0. Decimal point, but a fairly consequential one.

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u/salma_baptista52 points·4 months ago·edited

sulphur burps are disgusting but not dangerous, 20 weeks and they stopped

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u/marta_marchand41 points·4 months ago

resting heart rate moved up 15 bpm and settled back down when I stopped escalating

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u/gentle_correctionMOD46 points·4 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/hassan_castellanos22 points·4 months ago

Same experience. Week 41 and it simply stopped. I know that is not useful information but it is what happened.

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u/liv_vukovic30 points·4 months ago
the VendorInvestigate number or it did not happen
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u/ayesha_erdogan22 points·4 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/baseline_drifteranalytical18 points·4 months ago

This is correct. The early fullness is horrible for three weeks and then just ends.

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u/nausea_notesside effects0 points·4 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/milan_villalobos1 point·4 months ago

resting heart rate moved up 2 bpm and settled back down when I stopped escalating

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u/elin_lundgren1 point·4 months ago

resting heart rate moved up 2 bpm and settled back down when I stopped escalating

Adding to this: heart rate is doing more work than the comment implies.

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u/graph_it_gary9 points·4 months ago

severe abdominal pain is an urgent-care question, not a forum question

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u/neha_rahimi6 points·4 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/brigade_detector2 points·4 months ago

How many weeks in are you? 2 weeks is noise, 10 weeks is a trend.

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u/cesar_oyelaran1 point·4 months ago

Small correction: the trial was 14 weeks, not 31. Does not change your point but people will quote it.

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u/rekha_mbeki7 points·4 months ago

Half-life is about 168 hours, so steady state lands around week 3–5. Practical consequence: what you feel in week 1 is not what that dose does.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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