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c/survodutide·posted 1 year ago by u/diego_szabo

[Question] how do you actually verify biopsy

Question Well Actually ×4

Confession thread, sort of.

I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 10 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have muscle cramps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 94 reads it before doing the same thing.

0 up / 0 down43% upvoted5 commentsid 1vtbiu20 Jun 2025

5 comments

5 in this archive, depth 3

best — the order this archive was captured in

u/protein_first_pnutrition7 points·1 year ago

the heart rate signal is real in the data

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[removed]3 points·1 year ago

[removed by moderator]

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u/kaia_wojcik1 point·1 year ago

[removed by moderator]

Yes, exactly this, and it is the bit that took me 86 weeks to accept.

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u/yannick_petrov10 points·1 year ago·edited

Strongly agree. The safety story is separate.

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u/kaia_wojcik6 points·1 year ago

Week 55 for me and the honest summary is: 23kg down, reflux manageable, and I have thought about food maybe four times today.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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