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c/survodutide·submitted 1 year ago by u/titration_marshal

why does nobody talk about biopsy

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Right, the glucagon question again, but with numbers this time. I have 18 data points over 20 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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5 comments, started 1 year ago
u/diego_szabo251 points·1 year ago

glucagon co-agonism has a different safety story

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u/rafael_sjoberg118 points·1 year ago

glucagon co-agonism has a different safety story

Adding to this: hepatic fat is doing more work than the comment implies.

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u/titration_marshalOPmod · c/semaglutide60 points·1 year ago

Yeah, glucagon co-agonism is genuinely different.

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u/renzo_asante205 points·1 year ago

This is correct. Do not generalise from tirzepatide.

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u/liver_enzyme_liz122 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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