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c/survodutide·submitted 11 months ago by u/rania_salinas

[Discussion] we are measuring MASH at the wrong time and calling it noise

Discussionbranch of 12 comments

Trying to settle this properly because the thread from last year went in circles. The claim: MASH matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything. What would actually settle it is 5 people measuring the same thing…

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This branch

12 comments, started 10 months ago
u/incretin_ivypharmacology20 points·10 months ago

Came off after 80 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/neha_rahimi9 points·10 months ago

Slight fix: the number was 95.1, not 94.2. Decimal point, but a fairly consequential one.

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u/milos_mensa29 points·10 months ago

phase 4 data is interesting, phase 14 will be different

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u/rania_salinasOP9 points·10 months ago

Came off after 80 weeks for financial reasons.

Disagree on that part. 98.7% and 98.9% on the same vial is normal.

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u/samir_falk6 points·10 months ago

Came off after 80 weeks for financial reasons.

Disagree on that part. 98.1% and 98.3% on the same vial is normal.

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u/vitamin_d_void4 points·10 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/kian_ferreira3 points·10 months ago

the heart rate signal is real in the data

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u/renzo_yildiz2 points·10 months ago

the heart rate signal is real in the data

Yes, exactly this, and it is the bit that took me 6 weeks to accept.

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u/deleted_my_history1 point·10 months ago

do not generalise from tirzepatide

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u/honest_syringe_pls6 points·10 months ago

Came off after 80 weeks for financial reasons.

Disagree on that part. 97.6% and 97.9% on the same vial is normal.

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u/throwaway_wl20264 points·10 months ago

This is correct. Do not generalise from tirzepatide.

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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