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c/t2dglp1·posted 1 year ago by u/long_post_larry

A1c: what the trials say vs what this community says

CGM Clean Column ×2 Sourced ×1

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking T2D against triglycerides for 7 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

8,122 up / 7,187 down53% upvoted34 commentsid tvunxs21 Aug 2024

34 comments

21 in this archive, depth 4

best — the order this archive was captured in

u/a1c_arcMOD78 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/long_post_larryOP-16 points·1 year ago

Came off after 87 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/gradient_goblin27 points·1 year ago

the ApoB change is the signal

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u/piotr_bruun10 points·1 year ago

post A1c with units and assay date

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u/lyophile_lou32 points·1 year ago

Stalled for 13 weeks, changed nothing, and it started moving again on week 71.

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u/rafael_krastev26 points·1 year ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/plain_titration30 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/graph_it_gary37 points·1 year ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/long_post_larryOP22 points·1 year ago

Came off after 35 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/niels_salinas18 points·1 year ago

no medication-stopping advice, ever

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u/gradient_goblin8 points·1 year ago

no medication-stopping advice, ever

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/camila_sandvik6 points·1 year ago

the weight-loss conversation drowns out glycaemic control sometimes

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u/fridge_door_no4 points·1 year ago

Strongly agree. A1c matters as much as weight.

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u/emil_okwuosa24 points·1 year ago

Yeah, glycaemic control is the original use.

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u/long_post_larryOP18 points·1 year ago

post A1c with units and assay date

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u/ingrid_correia24 points·1 year ago

the fasting insulin change is the signal

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u/stablecoin_steve12 points·1 year ago

metformin combo is standard

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u/kian_verhoeven9 points·1 year ago·edited

metformin combo is standard

Adding to this: glycaemic control is doing more work than the comment implies.

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u/stablecoin_steve3 points·1 year ago

Did anything else change in the same window?

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u/nadia_norgaard2 points·1 year ago

the weight-loss conversation drowns out glycaemic control sometimes

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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  1. Insulin and sulfonylurea interactions are a real hypo risk. Do not hand-wave them.
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