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c/t2dglp1·posted 5 months ago by u/gentle_correction

three years of glycaemic control threads, summarised so you do not have to read them

Question Cold Box ×5

Confession thread, sort of.

I went from 1.7mg to 0.25mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 7 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have early fullness I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 7 reads it before doing the same thing.

410 up / 91 down82% upvoted26 commentsid yccl4x24 Feb 2026

26 comments

19 in this archive, depth 4

best — the order this archive was captured in

u/gentle_correctionMOD43 points·5 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/throwaway_918212 points·5 months ago

Yeah, glycaemic control is the original use.

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[removed]5 points·5 months ago

[removed by moderator]

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u/gentle_correctionOPnice about it2 points·5 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/fabio_lehtinen1 point·5 months ago

insulin and sulfonylurea interactions are real hypo risk

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u/joaquin_stanescu25 points·5 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/fasting_insulin_f19 points·5 months ago·edited

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/hassan_ostergaard6 points·5 months ago

CGM traces tell a story, numbers alone do not

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u/not_my_main_nm15 points·5 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/runa_grimaldi7 points·5 months ago·edited

A1c, CGM, stacking with metformin

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u/hana_lehtinen11 points·5 months ago

Strongly agree. A1c matters as much as weight.

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u/hana_lehtinen8 points·5 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/gentle_correctionOPnice about it3 points·5 months ago

type 2 is the indication, weight loss is the side effect

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u/tomas_kimani9 points·5 months ago

This is correct. Hypo risk is real.

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u/ingrid_correia4 points·5 months ago·edited

Maintenance for 7 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/graph_it_gary5 points·5 months ago

the 81 A1c trend is the answer

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u/camila_sandvik13 points·5 months ago

Strongly agree. A1c matters as much as weight.

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u/marisol_moreau10 points·5 months ago

I am going to push back on this slightly.

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u/gentle_correctionOPnice about it5 points·5 months ago

the triglycerides change is the signal

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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  1. Insulin and sulfonylurea interactions are a real hypo risk. Do not hand-wave them.
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