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c/tapering·posted 4 months ago by u/diego_szabo

interval stretching — my 5-week log, condensed into one table

Regain Clean Column ×1 Slow Clap ×3

appetite return. That is the whole post, but I will justify it.

Everything else people worry about in c/coa is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort appetite return out first, and almost nobody does.

I say this having got it wrong for 3 months. My triglycerides was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

1,064 up / 56 down95% upvoted66 commentsid 1jvsjl29 Mar 2026

66 comments

29 in this archive, depth 5

best — the order this archive was captured in

u/priya_guerrero241 points·4 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/taper_off_tabithaMOD149 points·4 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/diego_szaboOP78 points·4 months ago

This is an urgent-care question wearing a forum question's clothes.

Adding to this: discontinuation is doing more work than the comment implies.

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u/diego_szaboOP44 points·4 months ago

You have restated the marketing copy. What is the actual substance here.

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u/diego_szaboOP26 points·4 months ago

Maintenance for 10 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/viktor_laurent21 points·4 months ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/vial_math_verasyringe math142 points·4 months ago·edited

Second this question. I have wondered about interval stretching for 5 months and never seen a straight answer.

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u/ismael_eriksen41 points·4 months ago

Strongly agree. The regain is expected.

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u/liv_kuipers36 points·4 months ago

no shaming people who restart

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u/priya_weiss11 points·4 months ago

cite the discontinuation data rather than guessing regain rates

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u/maren_baptista152 points·4 months ago

Half-life is about 168 hours, so steady state lands around week 11–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/chain_confirm_cpayments90 points·4 months ago

Disagree. What you are describing is consistent with regain, not with what you concluded.

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u/ignacio_silva55 points·4 months ago

interval stretching versus dose reduction

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u/cormac_erdogan63 points·4 months ago

You have restated the marketing copy. What is the actual substance here.

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u/neha_krastev22 points·4 months ago

say how long you were on and at what dose before taper

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u/britta_boateng34 points·4 months ago

coming off deliberately, not by accident

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u/britta_boateng28 points·4 months ago

no shaming people who restart

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u/ismael_eriksen13 points·4 months ago·edited

Yeah, regain is not a failure.

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u/honest_syringe_20258 points·4 months ago

the 7 week discontinuation arm is the data

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u/salma_vasquez20 points·4 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/nikhil_lindqvist22 points·4 months ago

Yeah, regain is not a failure.

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u/vikram_ferreira14 points·4 months ago

cite the discontinuation data rather than guessing regain rates

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u/aleksi_lehtinen4 points·4 months ago

the regain is treatment of chronic condition ending, not failure

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u/maren_baptista-14 points·4 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/malin_petrescu26 points·4 months ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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