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c/tapering·posted 7 months ago by u/cormac_roos

the appetite return thing finally clicked for me and I want to write it down

Question Cold Box ×1

Week 37 update. 28kg down from the start, early fullness basically gone since about week 89.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

724 up / 121 down86% upvoted31 commentsid jt51x328 Dec 2025

31 comments

24 in this archive, depth 5

best — the order this archive was captured in

u/piotr_bruun124 points·7 months ago

Strongly agree. The regain is expected.

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u/cormac_roos58 points·7 months ago

The sulphur burps was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/hana_lehtinen82 points·7 months ago

Half-life is about 168 hours, so steady state lands around week 23–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/maren_baptista0 points·7 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/maintenance_mode_maxMOD45 points·7 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/cormac_roosOP26 points·7 months ago

appetite return timelines vary discontinuation

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u/ismael_eriksen58 points·7 months ago

interval stretching versus dose reduction

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[removed]27 points·7 months ago

[removed by moderator]

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u/ismael_eriksen7 points·7 months ago

Not to be pedantic but discontinuation and tapering are being used interchangeably and they are not interchangeable in real life.

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u/nayeli_fonseca22 points·7 months ago

say how long you were on and at what dose before taper

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u/source_or_silence12 points·7 months ago

This is correct. Discontinuation data is real.

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u/vial_math_verasyringe math22 points·7 months ago·edited

Strongly agree. The regain is expected.

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u/arne_amankwah-16 points·7 months ago

Yeah, regain is not a failure.

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u/dario_vermeulen1 point·7 months ago

no shaming people who restart

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u/rekha_teixeira1 point·7 months ago

Yeah, regain is not a failure.

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u/cormac_roosOP1 point·7 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/appeal_letter_al1 point·7 months ago

You have restated the marketing copy. What is the actual substance here.

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u/osman_eriksen9 points·7 months ago·edited

the 10 week discontinuation arm is the data

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u/quarter_dose_queenlow and slow3 points·7 months ago

Did anything else change in the same window?

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u/cormac_roosOP4 points·7 months ago

the regain is treatment of chronic condition ending, not failure

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u/lift_heavy_thingsresistance training3 points·7 months ago

cite the discontinuation data rather than guessing regain rates

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u/viktor_kirchner1 point·7 months ago·edited

Small correction: the trial was 8 weeks, not 6. Does not change your point but people will quote it.

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u/pavel_halvorsen1 point·7 months ago

Small correction: the trial was 8 weeks, not 6.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/border_paperwork6 points·7 months ago

the people who came off and restarted without shame

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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