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c/tirzepatide·submitted 2 years ago by u/hana_pereira

[Lab] split one vial across VendorInvestigate and PeptideMeter — 98.0% and 99.0%

Labbranch of 4 comments

Right, the Mounjaro question again, but with numbers this time. I have 19 data points over 24 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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4 comments, started 2 years ago
u/hair_shed_hannah3.2k points·2 years ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/ahmed_fonseca1k points·2 years ago·edited

My eGFR moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/teodor_szabo430 points·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

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u/taper_off_tabitha513 points·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

Yes, exactly this, and it is the bit that took me 77 weeks to accept.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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