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c/tirzepatide·submitted 2 years ago by u/tove_vasquez

[Results] 57 weeks, 20kg, and tirzepatide was the hard part

Resultsbranch of 8 comments

Confession thread, sort of. I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have sulphur…

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8 comments, started 2 years ago
u/fatima_wojcik1.1k points·2 years ago

week 89 on Mounjaro and the appetite profile is genuinely different from sema

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u/sten_palacios856 points·2 years ago

My fasting insulin moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/kaia_wojcik520 points·2 years ago

week 89 on Mounjaro and the appetite profile is genuinely different from sema

Yes, exactly this, and it is the bit that took me 3 weeks to accept.

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u/fatima_wojcik746 points·2 years ago

Hard agree. The food noise disappears differently on the two compounds.

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u/yusuf_ramos349 points·2 years ago·edited

the muscle cramps from tirz is different, not necessarily worse

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u/sofia_nascimento173 points·2 years ago

the dual agonism hits different and that is why people describe it differently

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u/curious_panel_only224 points·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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u/matias_salgado53 points·2 years ago

SURMOUNT data is messier than STEP data but the weight loss is there

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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